Head of Laboratory (f/m/d) Drug Metabolism (limited for 2 years )

With more than 1000 employees located in six research sites in Germany and France and a 40-year track record, the NUVISAN group is a science-driven contract research, development, and manufacturing organization. Our primary mission is to discover and develop promising drug candidates for our clients and partners from the pharmaceutical industry, startups, and biotech companies. NUVISAN provides integrated solutions from early research to phase II clinical trials to advance our partners’ products safely and effectively to the market.

Innovation Campus Berlin (ICB), NUVISAN´s discovery hub, focuses on early drug research. Located in the heart of Berlin, you will work in an international and diverse team of experts on the hunt for the next generation of small molecules and beyond.

Become part of an enthusiastic international team with a shared vision for the future

RESPONSIBILITIES

• Perform and report studies to identify, elucidate structurally and quantify metabolites from in vitro and in vivo experiments by applying state-of-the-art high-resolution mass spectrometry techniques
• Lead a small team of up to three lab technicians
• Organize and coordinate the work within the laboratory and ensure optimal use of resources
• Identify structural alerts and evaluate potentials risks associated with drug metabolites
• Discuss study results within interdisciplinary project teams, partners and clients
• Provide guidance for the structural optimization of compounds in pharma research projects
• Independent development, qualification and implementation of LC-MS methods to support the qualitative and quantitative analysis of drug and metabolites
• Evaluate and implement new technologies, software tools and methodologies in the field of drug metabolism and metabolite identification by mass spectrometry

QUALIFICATIONS

• PhD degree in chemistry, biochemistry, biomedical sciences, or a related field
• Hands-on experience and technical knowledge with UPLCs and mass spectrometry (ideally with Orbitrap systems), in particular high-resolution MS based structure elucidation of small molecules in complex biological matrices (i.e. plasma, excreta)
• Basic knowledge on bioanalysis method development and assay establishment
• Interest to elaborate expertise in modern biochemical in vitro techniques, as with the use recombinant enzymes, cellular fractions, hepatocytes and other cultured cells
• Understanding of drug metabolism assays and/or MALDI-MS imaging is a plus
• Experience with metabolite ID software tools (e.g. Compound Discoverer) or platforms (e.g. Webmetabase) is of advantage
• Interest in drug discovery, ADME and pharmacokinetics is desired
• Communicative, pro-active, problem solver who is highly organized with the ability to thrive in an environment with rapidly changing priorities
• Good written and oral presentation capabilities
• Proficiency in German and English

WE OFFER

• A two-year employment contract and an attractive salary package including a variable bonus payment
• Flexible working hours including a modern workplace 
• 30 days annual leave
• Company pension scheme
• Extensive health prevention offers
• Comprehensive introduction and individual training and development
• BVG job ticket and free parking spaces directly on-site
• A dynamic, future-oriented and employee-oriented company, with room for growth and your own ideas
• Interdisciplinary, agile teams with flat hierarchies
• Work on products and services with high social impact

As Nuvisan, we value diversity, promote equality and stand up against discrimination. We strive to create an inclusive work environment where everyone feels comfortable, regardless of gender identity, sexual orientation, disability, or ethnicity. We treat every applicant with the same respect and appreciation.